Description

ANTIBODYCONCENTRATION
Providedat0.5mg/mlin1XPBScontaining0.1%sodiumazideand50%glycerol.
ThismousemonoclonalantibodyisanIgG2bpurifiedfrommouseascites.
IMMUNOGEN
8-oxo-dG-conjugated-KLH
SPECIFICITY
This antibodyspecificallybindsto8-hydroxy-2′-deoxyguanosinewithinDNA.
STORAGE
Freezeinworkingaliquotsat-20°Cinamanualdefrostfreezer.
APPLICATIONS
ELISAandImmunocytochemistry

MyostatinInducesDNADamageinSkeletalMuscleofStreptozotocin-inducedType1DiabeticMice
Sriram,S.,Subramanian,S.,KumarJuvvuna,P.,McFarlane,P.,SennaSalerno,M.,Kambadur,R.,andSharma,M.
J.Biol.Chem.,Feb2014;289:5784–5798.
http://www.jbc.org/cgi/content/abstract/289/9/5784

MitochondrialOxidativeStress-InducedEpigeneticModificationsinPancreaticEpithelialCells
Mishra,P.K.,Raghuram,G.V.,Jain,D.,Jain,S.K.,Khare,N.K.andPathak,N.
InternationalJournalofToxicology,Mar2014;33:116–129
http://ijt.sagepub.com/cgi/content/abstract/33/2/116

Hrd1suppressesNrf2-mediatedcellularprotectionduringlivercirrhosis
TongdeWu,FeiZhao,BeixueGao,CanTan,NaokoYagishita,ToshihiroNakajima,PakK.Wong,EliChapman,DeyuFang,andDonnaD.Zhang
Genes&Dev.,Apr2014;28:708–722
http://genesdev.cshlp.org/cgi/content/abstract/28/7/708

Diabetes-InducedOxidativeDNADamageAltersp53-p21CIP1/Waf1SignalingintheRatTestis
Kilarkaje,N.andAl-Bader,M.M.,
ReproductiveSciences,May2014;10.1177/1933719114533729.
http://rsx.sagepub.com/cgi/content/abstract/1933719114533729v1

Prolactinpreventshepatocellularcarcinomabyrestrictinginnateimmuneactivationofc-Mycinmice
ArlinB.Rogers,HadleyJ.Hartwell,KeikoY.Petrosky,JamesG.Fox,NelsonD.Horseman,andArlinB.Rogers
PNAS,Aug2014;111:11455–11460.
http://www.pnas.org/cgi/content/abstract/111/31/11455

“Atg7OvercomesSenescenceandPromotesGrowthofBrafV600E-DrivenMelanoma”
XiaoqiXie,JuYongKoh,SandyPrice,EileenWhite,andJaniceM.Mehnert
CancerDiscovery,Apr2015;5:410–423.
http://cancerdiscovery.aacrjournals.org/cgi/content/abstract/5/4/410

“Nrf2-DependentSuppressionofAzoxymethane/DextranSulfateSodium–InducedColonCarcinogenesisbytheCinnamon-DerivedDietaryFactorCinnamaldehyde”
“MinLong,ShashaTao,MontserratRojodelaVega,TaoJiang,QingWen,SophiaL.Park,DonnaD.Zhang,andGeorgT.Wondrak”
CancerPreventionResearch,May2015;8:444–454.
http://cancerpreventionresearch.aacrjournals.org/cgi/content/abstract/8/5/444

hSSB1(NABP2/OBFC2B)isrequiredfortherepairof8-oxo-guaninebythehOGG1-mediatedbaseexcisionrepairpathway
NicolasPaquet,MarkN.Adams,VincentLeong,NicholasW.Ashton,ChristineTouma,RolandGamsjaeger,LizaCubeddu,SamBeard,JoshuaT.Burgess,EmmaBolderson,KenJ.O’Byrne,andDerekJ.Richard
NucleicAcidsRes.,Oct2015;43:8817–8829.
http://nar.oxfordjournals.org/cgi/content/abstract/43/18/8817

AnEssentialRoleofNRF2inDiabeticWoundHealing
MinLong,MontserratRojodelaVega,QingWen,ManishBharara,TaoJiang,RuiZhang,ShiwenZhou,PakK.Wong,GeorgT.Wondrak,HongtingZheng,andDonnaD.Zhang
Diabetes,Mar2016;65:780–793
http://diabetes.diabetesjournals.org/cgi/content/abstract/65/3/780

“MitochondrialtargetingofXJB-5-131attenuatesorimproves
pathophysiologyinHdhQ150animalswithwell-developeddisease
phenotypes”
“ArisPolyzos,AmyHolt,ChristopherBrown,CelicaCosme,PeterWipf,AlexGomez-Marin,MaríadelR.
Castro,SylvetteAyala-Peña,andCynthiaT.McMurray”
Hum.Mol.Genet.,Mar2016;10.1093/hmg/ddw051
http://hmg.oxfordjournals.org/cgi/content/abstract/ddw051v2

Sirt3protectsmitochondrialDNAdamageandblocksthedevelopmentofdoxorubicin-inducedcardiomyopathyinmice
VinodkumarB.Pillai,SamikBindu,WillSharp,YongHuFang,GeneKim,MadhuGupta,SadhanaSamant,andMaheshP.Gupta
AmJPhysiolHeartCircPhysiol,Apr2016;310:H962–H972.
http://ajpheart.physiology.org/cgi/content/abstract/310/8/H962

“L-Lactate-MediatedNeuroprotectionagainstGlutamate-InducedExcitotoxicityRequiresARALAR/AGC1”
IreneLlorente-Folch,CarlosB.Rueda,IrenePérez-Liébana,JorginaSatrústegui,andBeatrizPardo
J.Neurosci.,Apr2016;36:4443–4456.
http://www.jneurosci.org/cgi/content/abstract/36/16/4443

“EndothelinReceptorAAntagonismPreventsDamagetoGlycogen-RichPlacentalCellsFollowingUterineIschemia–ReperfusionintheRat”
LarryG.Thaete,SairaKhan,andMarkG.Neerhof
ReproductiveSciences,Apr2016;10.1177/1933719116645190.
http://rsx.sagepub.com/cgi/content/abstract/1933719116645190v1

TrajectoryofParvalbuminCellImpairmentandLossofCorticalInhibitioninTraumaticBrainInjury
Tsung-HsunHsieh,HenryHingCheongLee,MustafaQADIrHameed,AlvaroPascual-Leone,TakaoK.Hensch,andAlexanderRotenberg
CerebCortex,Nov2016;10.1093/cercor/bhw318.
http://cercor.oxfordjournals.org/cgi/content/abstract/bhw318v1

“EndothelinReceptorAAntagonismPreventsDamagetoGlycogen-Rich
PlacentalCellsFollowingUterineIschemia–ReperfusionintheRat”
LarryG.Thaete,SairaKhan,andMarkG.Neerhof
ReproductiveSciences,Nov2016;23:1518–1525.
http://rsx.sagepub.com/cgi/content/abstract/23/11/1518

OncogenicKRASConfersChemoresistancebyUpregulatingNRF2
ShashaTao,ShueWang,SeyedJavadMoghaddam,AiksengOoi,EliChapman,PakK.Wong,andDonnaD.Zhang
CancerRes.,Dec2014;74:7430–7441.
http://cancerres.aacrjournals.org/cgi/content/abstract/74/24/7430

DNAligaseIIIactsasaDNAstrandbreaksensorinthecellularorchestrationofDNAstrandbreakrepair
IsmailABDou,GuyG.Poirier,MichaelJ.Hendzel,andMichaelWeinfeld
NucleicAcidsRes.,Jan2015;43:875–892
http://nar.oxfordjournals.org/cgi/content/abstract/43/2/875

Trevigen提供多种产品来测量氧化应激和DNA损伤。我们的彗星实验®产品线是为彗星试验，其中包括试剂，试剂盒，设备和分析软件的唯一完整和优化的商用平台。我们的TACS ®（Trevigen公司凋亡的细胞系统）产品已被广泛使用，并列举多年来，研究人员对他们的无与伦比的品质认可。