Description

CONCENTRATION
100unitspervial
SOURCE
PurifiedfromE.colicontainingarecombinantplasmidharboringtheα-hOGG1gene(nuclearprotein).
SUBSTRATESPECIFICITY
ThecatalyticactivityofhOGG1isdependentuponthebasethe8-oxoGispairedwithintheorderofC>T>G,A. hOGG1isalsocatalyticallyactivewhenFaPyispairedwithC.FaPyisonlyrepairedwhenbasepairedtocytosine.
STORAGE
Storeat-20°Cinamanualdefrostfreezer.Forlong-termstorage,freezeat-80°Cinworkingaliquots.
APPLICATIONS
DNARepairAssays
FLARE™

“InfluenceofOxidizedPurineProcessingonStrand
DirectionalityofMismatchRepair”
SimoneRepmann,MaiteOlivera-Harris,andJosefJiricny
J.Biol.Chem.,Apr2015;290:9986–9999
http://www.jbc.org/cgi/content/abstract/290/16/9986

FormationandRepairofMismatchesContainingRibonucleotidesandOxidizedBasesatRepeatedDNASequences
PieraCilli,AnnaMinoprio,CeciliaBossa,MargheritaBignami,andFilomenaMazzei
J.Biol.Chem.,Oct2015;290:26259–26269.
http://www.jbc.org/cgi/content/abstract/290/43/26259

OxidizeddNTPsandtheOGG1andMUTYHDNAglycosylasescombinetoinduceCAG/CTGrepeatinstABIlity
PieraCilli,IleniaVentura,AnnaMinoprio,EttoreMeccia,AlbertoMartire,SamuelH.Wilson,MargheritaBignami,andFilomenaMazzei
NucleicAcidsRes.,Mar2016;10.1093/nar/gkw170
http://nar.oxfordjournals.org/cgi/content/abstract/gkw170v1

“OxidizeddNTPsandtheOGG1andMUTYHDNAglycosylasescombine
toinduceCAG/CTGrepeatinstability”
“PieraCilli,IleniaVentura,AnnaMinoprio,EttoreMeccia,AlbertoMartire,SamuelH.Wilson,MargheritaBignami,andFilomenaMazzei”
NucleicAcidsRes.,Jun2016;44:5190–5203.
http://nar.oxfordjournals.org/cgi/content/abstract/44/11/5190

“Weaksilicananomaterial-inducedgenotoxicitycanbeexplainedby
indirectDNAdamageasshownbytheOGG1-modifiedcometassayand
genomicanalysis”
StefanPfuhler,ThomasR.Downs,AshleyJ.Allemang,YuchingShan,andMeredithE.CrosbyMutagenesis,Nov2016;10.1093/mutage/gew064.
http://mutage.oxfordjournals.org/cgi/content/abstract/gew064v1

Trevigen提供多种产品来测量氧化应激和DNA损伤。我们的彗星实验®产品线是为彗星试验，其中包括试剂，试剂盒，设备和分析软件的唯一完整和优化的商用平台。我们的TACS ®（Trevigen公司凋亡的细胞系统）产品已被广泛使用，并列举多年来，研究人员对他们的无与伦比的品质认可。