Description
Althoughtheentiresignalingpathwaysmediatingetoposide-inducedapoptosisarenotclear,double-strandedandsingle-strandedDNAbreaksinducedbyetoposidehavebeenshowntoactivatethep53activitybyphosphorylation,resultinginanup-regulationofthepro-apoptoticproteinBax.ThetranslocationofBaxtothemitochondriainducestheMPT,theeventthatreleasescytochromecandculminatesinthedeathofthecells.EtoposidealsoblocksthecellcycleinS-phaseandG2-phase;inducesapoptosisinnormalandtumorcelllines;inhibitssynthesisoftheoncoproteinMdm2andinducesapoptosisintumorlinesthatoverexpressMdm2.
PhysicalState:EtoposideisprovidedinDMSO.Thefinalreagentconcentrationis10mM.
Trevigen提供多种产品来测量氧化应激和DNA损伤。我们的彗星实验®产品线是为彗星试验，其中包括试剂，试剂盒，设备和分析软件的唯一完整和优化的商用平台。我们的TACS ®（Trevigen公司凋亡的细胞系统）产品已被广泛使用，并列举多年来，研究人员对他们的无与伦比的品质认可。
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