Description

Cultrex®BasementMembraneExtract(BME)isasolubleformofbasementmembranepurifiedfromEngelbreth-Holm-Swarm(EHS)tumor.Thisextractprovidesanaturalextracellularmatrixhydrogelthatpolymerizesat37°Ctoformareconstitutedbasementmembrane.Basementmembranesarecontinuoussheetsofspecializedextracellularmatrixthatformaninterfacebetweenendothelial,epithelial,muscle,orneuronalcellsandtheiradjacentstromaandthatplayanessentialroleintissueorganizationbyinfluencingcelladhesion,migration,proliferation,anddifferentiation.ThemajorcomponentsofBMEincludelaminin,collagenIV,entactin,andheparinsulfateproteoglycans.

TheCultrex®BME CellInvasionAssayprovidesatoolforassessingcellinvasionthroughareconstitutedbasementmembraneandisavailablein24and96wellformats.

HypermethylationoftheGABREtextasciitildemiR-452textasciitildemiR-224PromoterinProstateCancerPredictsBiochemicalRecurrenceafterRADIcalProstatectomy,
HelleKristensen,ChristaHaldrup,SiriStrand,KamillaMundbjerg,MartinM.Mortensen,KasperThorsen,MarieStampeOstenfeld,PeterJ.Wild,ChristianArsov,WolfgangGoering,TapioVisakorpi,LarsEgevad,JohanLindberg,HenrikGrönberg,SørenHøyer,MichaelBorre,TorbenF.Ørntoft,andKarinaD.Sørensen
Clin.CancerRes.,Apr2014;20:2169–2181.
http://clincancerres.aacrjournals.org/cgi/content/abstract/20/8/2169

1α,25-DihydroxyvitaminD3InhibitsEsophagealSquamousCellCarcinomaProgressionbyReducingIL6Signaling
Ping-TsungChen,Ching-ChuanHsieh,Chun-TeWu,Tzu-ChenYen,Paul-YangLin,Wen-ChengChen,andMiao-FenChen
Mol.CancerTher.,Jun2015;14:1365–1375.
http://mct.aacrjournals.org/cgi/content/abstract/14/6/1365

ReciprocalregulationofaminoacidimportandepigeneticstatethroughLat1andEZH2
StephenGDann,MichaelRyskin,AnthonyMBarsotti,JonathonGolas,CelineShi,MiriamMiranda,ChristineHosselet,LuannaLemon,JudyLucas,MahaKarnoub,FangWang,JeremySMyers,ScottJGarza,MaximillianTFollettie,KennethGGeles,AnkeKlippel,RobertARollins,andValeriaRFantin
EMBOJ.,Jul2015;34:1773–1785.
http://EMBOJ.embopress.org/cgi/content/abstract/34/13/1773

“Semaphorin3Dautocrinesignalingmediatesthemetastaticroleof
annexinA2inpancreaticcancer”
“KellyFoley,AgnieszkaA.Rucki,QianXiao,DongerZhou,AshleyLeubner,GuanglanMo,Jennifer
Kleponis,AnnieA.Wu,RajniSharma,QingguangJiang,RobertA.Anders,ChristineA.Iacobuzio-
Donahue,KatherineA.Hajjar,AnirbanMaitra,ElizabethM.Jaffee,andLeiZheng”
Sci.Signal.,Aug2015;8:ra77.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;8/388/ra77

EukaryoticTranslationInitiationFactor5A(EIF5A)RegulatesPancreaticCancerMetastasisbyModulatingRhoAandRho-associatedKinase(ROCK)ProteinExpressionLevels
KenFujimura,SunkyuChoi,MeghanWyse,JanStrnadel,TracyWright,andRichardKlemke
J.Biol.Chem.,Dec2015;290:29907–29919.
http://www.jbc.org/cgi/content/abstract/290/50/29907

“ExtracellularandLuminalpHRegulationbyVacuolarH+-ATPase
IsoformExpressionandTargetingtothePlasmaMembraneand
Endosomes”
GinaA.Smith,GarethJ.Howell,ClairPhillips,StephenP.Muench,SreenivasanPonnambalam,andMichaelA.Harrison
J.Biol.Chem.,Apr2016;291:8500–8515.
http://www.jbc.org/cgi/content/abstract/291/16/8500

TheMCT4Gene:ANovel,PotentialTargetforTherapyofAdvancedProstateCancer
“StephenYiuChuenChoi,HuiXue,RebeccaWu,LadanFazli,DongLin,ColinC.Collins,MartinE.Gleave,
PeterW.Gout,andYuzhuoWang”
Clin.CancerRes.,Jun2016;22:2721–2733.
http://clincancerres.aacrjournals.org/cgi/content/abstract/22/11/2721

Trevigen提供多种产品来测量氧化应激和DNA损伤。我们的彗星实验®产品线是为彗星试验，其中包括试剂，试剂盒，设备和分析软件的唯一完整和优化的商用平台。我们的TACS ®（Trevigen公司凋亡的细胞系统）产品已被广泛使用，并列举多年来，研究人员对他们的无与伦比的品质认可。